IL6 and infection: Early in IAV infection of DIO mice, the expression of IL-6, TNFα, and type I interferons (IFNs) is delayed and reduced compared to that in LN mice, and differential regulation of IL-2 and IL-12 is detected in lung homogenates, whereas later in infection there is increased inflammation in DIO mice as compared to LN mice later in infection (26, 55, 64).