The union of β2GP1 that circulates physiologically through the blood in circular form to anionic superstructures from microorganisms, or from injured endothelium in situations such as infections, surgery or traumatisms could result in a change in the conformation to the fishhook form and exposing the cryptic epitopes of the Face L. To further test the validity of this hypothesis, it is essential to have crystallographic data of the circular conformation, a task that will require assistance from the research community. The gene discussed is APOH; the disease is infection.