A cohort of 86 SLE patients (Tables 1–5) and 30 healthy controls (19 females [63.3 %], 11 males [36.7%], age: 49.33 ± 7.68 years) was studied to determine the occurrence of AmtRNA-IgG and AmtRNA-IgM in human SLE. The gene discussed is CD40LG; the disease is systemic lupus erythematosus.