IL-1 family, moderate risk of infection, IL-6 and IL-6 receptor (JAK), similar to TNF. Neutropenia in some cases C5 targeted, Aspergillus encapsulated bacteria, specially Neisseria, IL-17 upper respiratory tract infections and Candida IgE helminth infection, Strongyloides. The gene discussed is IL17A; the disease is Recurrent upper respiratory tract infections.