Similarly, 2,3,4′,5-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) of Polygonum multiflorum provides neuroprotection in cerebral ischemia by inhibiting NF-κB-signaling and activating SIRT1 (41, 73). The gene discussed is NFKB1; the disease is Cerebral ischemia.