For example, TLR2 (153), TLR9 (154), MyD88 (154–156) and IRF-3 (157) deficiency resulted in protective effects in neuroinflammatory models, while TLR4 (156), TLR2 (118), and TRIF (158) deficiency presented aggravating disease, indicating the complex role of TLRs in inflammatory development in MS. Here, TLR4 is linked to myeloid sarcoma.