Infection of mice with S. aureus-induced an early inflammatory cytokine response with high levels of IL-1α, IL-1β, IFN-β, TNF-α, IL-6, IL-12p70, IL-27, and IFN-γ in the spleen detected for up to 12 h pi compared to PBS-treated mice (Figure 3). This evidence concerns the gene IL1B and infection.