These include: (1) HMW-HA strengthens cell-cell junctions and decreases the permeability of ECM, thus preventing invasion (103); (2) HMW-HA promotes tight junction formation and myosin polymerization in lymphatics by displacing LMW-HA from the LYVE-1 receptor, which restricts invasion into lymph nodes (103); (3) HMW-HA blocks migration by enhancing NF2 and CD44 co-association, which activates the tumor suppressor properties of CD44 (24); and (4) HMW-HA modifies the motogenic effects of growth factor signaling. This evidence concerns the gene CD44 and neoplasm.