HMMR and neoplasm: Tumor cell migration stimulated by LMW-HA is often associated with an epithelial-mesenchymal transition mediated by CD44 through activating PI3K/AKT and TGFβ signaling (65), while RHAMM is linked to increasing tumor cell migration via regulating ERK (77–79) and AURKA/beta-catenin pathways (80, 81).