The soluble form of B7-H6 is detected in the serum of patients with hepatocellular carcinoma (110), metastatic gastrointestinal tumors (GIST) (111), neuroblastoma (112, 113), and peritoneal fluid from ovarian cancer patients (114), and is associated with impaired NKp30 expression and NK cell dysfunction as well as poor overall patient survival. This evidence concerns the gene NCR3LG1 and ovarian cancer.