Cross-linking with anti-NKp46 mAb results in calcium release and the secretion of IFN-γ and TNF-α by NK cells and blocking NKp46 signaling with specific mAbs can result in reduced NK cell cytotoxicity of certain tumor cell-lines, although the most potent blocking activity is observed in combination with mAbs to other NCRs (19, 21). This evidence concerns the gene IFNG and neoplasm.