NCR3 and cancer: Yet another therapeutic strategy has been to engineer chimeric antigen receptor (CAR) constructs that incorporate either the NKp30 ectodomain (NKp30-CAR) or an anti-B7-H6 scFv (B7H6-specific CAR) with TM domains fused to the CD3ζ or and/or CD28 cytoplasmic signaling domains for cell-surface expression in T or NK cells intended for use in adoptive cancer immunotherapy (194–196).