NCR3LG1 and neuroblastoma: In pediatric neuroblastoma, expression of the immunostimulatory (NKp30a/b) versus immunosuppressive (NKp30c) isoforms is also associated with a higher risk of relapse and elevated serum levels of soluble B7-H6 that inhibit NK function were associated with the bone marrow metastasis and chemoresistance of neuroblastoma cells (112, 113).