TRAIL expression can be induced on NK cells activated by various cytokines and interferons (135–137) and several reports have described NK cell-mediated clearance of TRAIL-sensitive transplantable tumors (135, 138), chemical-induced fibrosarcoma (139), liver metastases (135, 139, 140), and hematological malignancies (141). The gene discussed is TNFSF10; the disease is fibrosarcoma.