Interestingly, the two non-synonymous IDO2 SNPs, rs10109853 (NP_919270.2:p.Arg248Trp), and rs4503083 (NP_919270.2:p.Tyr359Ter), which profoundly impair IDO2 activity, were not associated with A. fumigatus infection in CF patients (Table 4). This evidence concerns the gene IDO2 and cystic fibrosis.