In the setting of fungal infection, our group has shown that IDO1 rs3808606 T/T genotype correlated with a decreased susceptibility to recurrent vulvovaginal candidiasis and was associated with high levels of IL-22 and decreased levels of IL-17A and TNFα, enhanced IDO1 expression in vaginal cells and increased kynurenine-to-tryptophan ratio (11). This evidence concerns the gene IDO1 and fungal infectious disease.