In the renal lesions of LN patients and lupus mice, NF-κB pathway activation was found; at the same time, downstream factors regulated by the NF-κB classical pathway, such as TNF-α, IL-1β, IL-6, and intercellular adhesion molecules—The expression of 1 (ICAM-1) and the like also increased significantly. The gene discussed is TNF; the disease is systemic lupus erythematosus.