Therefore, NK cells in tissue may necessitate increased glycolytic activity while maintenance of memory-like populations marked by CD57 and CD16 expression as well as enhanced cytotoxic capacity – akin to memory CD8+ T cells – might require FAO (Kared et al., 2016; Peng and Tian, 2017), although this demands formal testing using ex vivo material from healthy subjects as well as in patients with infections (e.g., TB), or malignancies. This evidence concerns the gene CD8A and tuberculosis.