Resveratrol-mediated SIRT1 activation has been shown to interrupt the pro-inflammatory activity of CD4+ T cells (Zou et al., 2013), while myeloid cell-specific inactivation of the SIRT1 gene in a murine model of pulmonary TB resulted in amelioration of lung pathology, resolution of chronic inflammation and improved responses to anti-TB drug treatment (Cheng et al., 2017). The gene discussed is CD4; the disease is tuberculosis.