Researchers believe that the most clinically significant approach to combat this limitation is to develop novel gene vectors or effectively enhance the specific expression of HSV-TK by linking transcriptional regulatory elements such as tumor-specific promoters and enhancers and identifying the appropriate gene vector is also key to guaranteeing high security and efficiency in suicide gene therapy (Qiu et al., 2012; Hossain et al., 2016). The gene discussed is TKT; the disease is neoplasm.