Given that lissencephaly has been described in MDC1A-patients (37) increase of this protein not only accords with the concept of activation of proteins involved in neuroprotection (in none of our patients lissencephaly was found via MRI) but also provides a first molecular hint to the manifestation of lissencephaly in the etiopathology of MDC1A. The gene discussed is LAMA2; the disease is lissencephaly spectrum disorders.