Moreover, editing of the Htr2c transcript is observed within both the dorsolateral prefrontal cortex (PFC) (BA9) and anterior cingulate cortex (BA24) of patients with major depressive disorder (MDD), indicative of the translational relevance of investigating stress-induced regulation of well-conserved editing sites in rodent models of acute and chronic stress (15, 16). The gene discussed is HTR2C; the disease is major depressive disorder.