For example, genetic syndromes associated with ASD, including patients with Phelan–McDermid syndrome (33), WDR45 (17), 22q13 duplication (21), and Rett syndrome (18), as well as the PTEN haploinsufficient mouse model of ASD (16) have demonstrated significant elevations in ETC function. The gene discussed is PTEN; the disease is Rett syndrome.