Following ibuprofen treatment a reduction in the fold expression of proinflammatory mediators IL-1β (−2.27), IL-5 (−6.54), IL-6 (−11.35), IL-18 (−4.13), TNFα (−13.50), and CXCL10 (−63.56) were evident in IUGR treated piglets compared to IUGR untreated piglets (Figure 1F). This evidence concerns the gene IL18 and fetal growth restriction.