Ibuprofen treatment significantly alleviated the increase in Iba-1-positive activated microglia in the parietal cortex (54.7%; p < 0.0001), IGWM (44.2%; p < 0.0001), SCWM (39.5%; IUGR 75.14 ± 2.96; IUGR+Ibu: 45.68 ± 4.87; p = 0.0008), and PVWM (52.4%; IUGR: 97.27 ± 2.46; IUGR+Ibu: 46.26 ± 4.02; p < 0.0001) in treated IUGR piglets compared to untreated IUGR piglets (Figure 2). This evidence concerns the gene AIF1 and fetal growth restriction.