Neuromuscular impairment or mental retardation are rare complication sometimes reported in GPI deficiency (Van Biervliet et al., 1975; Kahn et al., 1978; Zanella et al., 1980; Shalev et al., 1993; Kugler et al., 1998; Jamwal et al., 2017), as well as in other glycolytic enzyme defects caused by ubiquitously expressed genes (i.e., phosphoglycerate kinase deficiency, phosphofructokinase deficiency or triosephosphate isomerase deficiency). This evidence concerns the gene HK1 and hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency.