For instance, the response to hypoglycemia seems to be fast, occurring within 60 min in one study (Page et al., 2009), whereas the CNS-mediated insulin effects are not evident until after 180 min according to some studies (Obici et al., 2002c; Ramnanan et al., 2011; Dash et al., 2015a). The gene discussed is INS; the disease is Hypoglycemia.