↓ARC activity on fMRI directly after glucose ingestion predicted subsequent insulin levels; Hypoglycemia induced changes in hypothalamus activity prior to rise in CRH in healthy subjects; ↓Brain responses to hypoglycemia associated with attenuated levels of CRH in T1D with HU; CNS glucose uptake correlates negatively with insulin sensitivity. The gene discussed is CRH; the disease is Hypoglycemia.