Recent report shows that chronic i.p. injection with spexin diminished hepatic lipids, serum alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in mice with hepatic steatosis/nonalcoholic fatty liver disease (HS/NAFLD; Jasmine et al., 2016). The gene discussed is GPT; the disease is metabolic dysfunction-associated steatotic liver disease.