In adolescent patients with obesity or T2MD, the circulating spexin level is inversely correlated with blood glucose, leptin, lipids, etc. However, in adult patients with obesity or T2MD, the circulating spexin level does not exhibit a correlation with blood glucose, leptin, triglyceride (TG), etc. (Hodges et al., 2018). This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.