Upstream regulator predictions suggested that six inflammatory cytokines were upregulated and one downregulated (Z-Score > 1 or <−1); among the upregulated cytokines, the classical Th2 cytokines interleukin (IL)-4 and IL-5 drive M2 macrophage polarization in asthma pathogenesis (Table 6). Here, IL4 is linked to asthma.