Among the well-studied AD drug targets (Silva et al., 2014), we found their dysregulation, such as the amyloid precursor protein gene (APP, 136 partners), glycogen synthase kinase 3 beta (GSK3B, 34 partners) and BACE1 (8 partners), suggesting their transcriptional involvement in the progression of AD. The gene discussed is APP; the disease is Alzheimer disease.