Based on the results from this study (Nosratabadi et al., 2016) combined with our results showing that astrocytic IL-6 is critical to hyperforin-mediated promoting effects on post-stroke neuroangiogenesis, we investigated the effects of IL-6 on the regulation of Th1/Th2 and Tregs response in the ischemic hemisphere during stroke recovery. This evidence concerns the gene IL6 and stroke disorder.