In our present study, examining the balance of local cytokine production in the ischemic hemisphere revealed a significant increase in the ratio of IL-4/IFN-γ after the treatment with hyperforin during stroke recovery, indicating that hyperforin could shift the balance of cytokine production from Th1 to Th2, which might add to the immunosuppressive environment of the neuroangiogenesis. This evidence concerns the gene IL4 and Stroke.