In line with this, genetic ablation of vglut3 in mice was shown to predispose to cocaine abuse (Sakae et al., 2015), however, the authors reported that this mechanism is likely independent of 5-HT signaling but rather linked to an increased dopamine and glutamate signaling in the NAc, from VTA dopaminergic and cortical glutamatergic inputs, respectively. Here, HTR5A is linked to cocaine abuse.