Since these behaviors are also dependent upon SERT activity/blockade by serotonergic antidepressant, whether VGLUT3 and SERT segregate or colocalize within 5-HT varicosities in the hippocampus is question of great interest and could further help in developing improved therapeutics for the treatment of anxiety- or depression-related disorders. The gene discussed is SLC17A8; the disease is Anxiety.