Furthermore, genetic ablation of VGLUT3 in mice (vglut3-/-) produces increased anxiety (Amilhon et al., 2010; Sakae et al., 2018), enhanced fear and altered stress axis regulation (Balázsfi et al., 2018), concomitant to the desensitization of 5-HT1A autoreceptors (Amilhon et al., 2010), suggesting a potential cross-regulation between 5-HT1A receptors and glutamate co-release. This evidence concerns the gene HTR1A and Anxiety.