GFAP and ischemia: Kim et al. (2013) analyzed 5 points in time (3, 7, 14, 21, and 28 days) via immunohistochemistry and displayed progressive gliosis in retinae that underwent pressure-induced ischemia. Another study by Mages et al. (2019) determined an GFAP up-regulation in Müller cells at 3 days post I/R, with a constantly high level of protein as well as mRNA up to 14 days.