miR-376c could repress the malignant behavior of glioma cells by repressing FOXP2 (Li et al., 2019) and circulating miR-376c was significantly down-regulated in serum from glioma patients when compared with healthy control (Huang et al., 2017), suggesting that miR-376c is a potential diagnostic marker and treatment target for glioma. This evidence concerns the gene FOXP2 and central nervous system cancer.