In the same study that identified RIN3 hypomethylation, no group-wide significant differences were observed for late-onset genes PTK2β, ABCA7, SIRT1, or MEF2C (although 1 CpG of MEF2C did have reduced methylation in one AD individual) (Boden et al., 2017). The gene discussed is RIN3; the disease is Alzheimer disease.