MAPT and Alzheimer disease: Narayan et al. (2015) for instance, utilized immunolabeling and microarray analyses to demonstrate increased H3 and H4 acetyl levels in post-mortem AD inferior temporal gyrus and middle temporal gyrus brain tissues compared to normal brain tissue, along with compromised protein degradation mechanisms. Observed differences significantly correlated with tau, β-amyloid, and ubiquitin pathology, as they were only present in areas associated with pathology and were not identified in the control cerebellum tissues (Narayan et al., 2015).