Beyond BD, bisulfite pyrosequencing demonstrates that ANK1 hypermethylation is not only observed in AD, but is also observed in Huntington’s disease and Parkinson’s disease, whereas samples with Vascular Dementia or Lewy bodies Dementia also demonstrated ANK1 hypermethylation, but only when they had coexisting AD-pathology (Smith et al., 2019). This evidence concerns the gene ANK1 and Alzheimer disease.