Upon examination of methylation, transcription, and expression of BMAL1, which is a known as a core component of the circadian rhythm clock and acts as a transcription factor that regulates the firing rate of hypothalamic suprachiasmatic nucleus neurons (Rudic et al., 2004), aberrant rhythmic methylation patterns significantly altering the expression of BMAL1 have been observed in fibroblasts and post-mortem AD brain samples (Cronin et al., 2017). The gene discussed is BMAL1; the disease is Alzheimer disease.