CCK and Anxiety: Cck expression positively related to levels of anxiety in the EPM (time open arm: ρ = -0.299, p = 0.039; Figure 6A) and Cck-related DNA methylation showed an opposing relationship with anxiety (time open arm: ρ = 0.381, p = 0.009; Figure 6B; closed arm: ρ = -0.304, p = 0.040; Figure 6D; distance on open arms: ρ = 0.403, p = 0.005; data not shown).