Transcriptome studies have revealed deregulation of the ALP in PD brains and alterations of several autophagy-related processes, including mTOR, PI3K/AKT, and 14-3-3 protein signalings (Elstner et al., 2011; Mutez et al., 2014; Dijkstra et al., 2015). The gene discussed is MTOR; the disease is Parkinson disease.