APP and Alzheimer disease: Interestingly, BFCN homogenates demonstrated oligomeric Aβ species of a variety of sizes, with increased levels of a cluster of bands between ∼35 and 44 kDa in non-demented elderly, and to a greater extent, in AD, in the absence of increases in either APP or total Aβ (Baker-Nigh et al., 2015).