Furthermore, the expression levels of genes encoding NLR proteins (NLRP12, NOD2, NOD1, NLRC4, and NAIP), inflammasome adaptor molecules (PYCARD), and proinflammatory caspases (CASP1, CASP4, and CASP5) were significantly higher in glioma patients than in normal controls (Supplementary Fig. S1g). Here, NLRP12 is linked to central nervous system cancer.