Furthermore, the expression levels of genes encoding NLR proteins (NLRP12, NOD2, NOD1, NLRC4, and NAIP), inflammasome adaptor molecules (PYCARD), and proinflammatory caspases (CASP1, CASP4, and CASP5) were significantly higher in glioma patients than in normal controls (Supplementary Fig. S1g). The gene discussed is CASP4; the disease is central nervous system cancer.