APOE and Peripheral demyelination: We determined Loes scores of the young males in this cohort and found those carrying APOE4 had a significantly more MRI white matter involvement with a mean Loes score of 10.5 compared to APOE4 non-carriers with a mean Loes score of 7 (p = 0.01) suggesting that more demyelination was present in young males carrying APOE4 (Fig. 3C).