Lox-Stop-Lox-KrasG12D mice develop non-small-cell lung carcinomas (NSCLCs) upon Cre deletion and induction of the mutant KrasG12D allele in a stepwise process that leads from epithelial hyperplasia to benign adenomas and malignant adenocarcinomas.12,13 We achieved expression of KrasG12D and simultaneous deletion of Aif following adenoviral delivery of Cre recombinase (AdCre) through inhalation using the Ad5-CMV-Cre or Ad5-mSPC-Cre virus (Supplementary information, Fig. S1a). This evidence concerns the gene AIFM1 and non-small cell lung carcinoma.