AIFM1 and adenocarcinoma: At 8 weeks and 16 weeks after Ad5-CMV-Cre infection, we observed markedly less tumor burden, in particular, reduced numbers of adenocarcinomas in Aiffl/yKrasG12D as compared to Aif+/yKrasG12D mice; restoration of AIF expression with WT as well as mitochondria-anchored AIF resulted in increased adenomas and adenocarcinomas, phenocopying the control mice that express endogenous AIF (Supplementary information, Fig. S8b, c).