AIFM1 and infection: In the resulting mouse lines, infection with Ad5-CMV-Cre resulted in KrasG12D induction, deletion of the endogenous Aif gene, and the additional deletion of the Lox-Stop-Lox cassette in the 5′ UTR of the knock-in Aif transgenes, thereby replacing endogenous AIF by either WT AIF or mitochondria-anchored mutant AIF (Supplementary information, Fig. S7a).