MYC and cancer: NFY binds to the CCAAT box, an element that has frequently been found to be enriched in promoters of genes overexpressed in tumours and to regulate metabolic pathways altered in cancer.28 Interestingly, despite the similar pathways that were upregulated in HCT116 and HKe3-mtKRAS cells, HCT116 upregulated genes were enriched for MYC-binding sites, not NFY-binding sites (data not shown).