To investigate the reprogramming of the transcriptional networks downstream of the EGFR pathway in wild type and mutant KRAS cells, we profiled transcriptome-wide gene expression in two HKe3 CRC cell lines which had been retrovirally transfected to re-express either the G13D mutant or wild-type versions of the KRAS gene7 and in HCT116 cells, which endogenously express KRASG13D. This evidence concerns the gene EGFR and colorectal carcinoma.