It is now well-established that treatment of metastatic CRC with antibodies (Cetuximab and Panitumumab) against the epidermal growth factor receptor (EGFR) is effective only among patients with wild-type KRAS (wtKRAS) carcinomas, whereas mutant KRAS (mtKRAS) carcinomas are resistant to this treatment.2 Here, EGFR is linked to carcinoma.