FNDC5 and Stroke: Only irisin was significantly associated with hypertension-related stroke (OR = 1.001, 95% CI: 1.00–1.001; P < 0.05) after adjusting for age, gender and exercise frequency (Table 6), and irisin and musclin were not correlated with SBP or DBP in the subgroup with stroke (Supplemental Table 4).