On average, the serum of patients with hypertension contained 456.9 ± 57.92 pg/ml irisin and 72.05 ± 1.41 pg/ml musclin, while the serum of patients with hypertension-related stroke contained 1333 ± 637.8 pg/ml irisin and 97.45 ± 25.62 pg/ml musclin. This evidence concerns the gene FNDC5 and hypertensive disorder.