FNDC5 and hypertensive disorder: In addition, logistic regression analysis was also performed to test the associations of DKK1, BDNF, FSTL1, leptin and irisin with hypertension, and irisin was significantly associated with hypertension (OR = 1.013, 95% CI: 1.002–1.025; P < 0.05) after adjusting for age, gender, height, BMI, FBG, HbA1c, TC level, Cre level, eGFR, exercise frequency and exercise duration, while DKK1 was associated with hypertension (OR = 0.995, 95% CI: 0.99–0.999; P < 0.05) in a complete model including all the covariates (Table 4).