Only irisin was significantly associated with hypertension-related stroke (OR = 1.001, 95% CI: 1.00–1.001; P < 0.05) after adjusting for age, gender and exercise frequency (Table 6), and irisin and musclin were not correlated with SBP or DBP in the subgroup with stroke (Supplemental Table 4). Here, FNDC5 is linked to Hypertension.