The most common somatic mutation concerning for cancer predisposition was TP53, associated with Li-Fraumeni syndrome, followed by NF1, NF2, BRCA2, WT1, RB1, APC, and PTEN. While some of these alterations are somatic changes only and tumor testing alone is not sufficient to diagnose germline conditions, the panel results allow for timely identification of patients to refer for genetic counseling and potential germline testing for a variety of cancer predisposition syndromes that may have important clinical implications for the patient and/or family members. The gene discussed is APC; the disease is Li-Fraumeni syndrome.