For example, SIN3A as a transcriptional regulator, UHRF1 as epigenetic regulatory factors, EPS15 as epidermal Growth Factor Receptor Pathway Substrate, RACGAP1 as a GTPase-activating protein (GAP), CDC16 as a component of the anaphase promoting complex/cyclosome (APC/C) and TUBG2 as a tubulin were all proved to be targeted (Additional file 11), which altogether influence the way CRKL regulates cervical cancer. The gene discussed is APC; the disease is cervical carcinoma.