As GALC GE-NSCs are overexpressing active GALC enzyme and releasing it into the culture media, we performed co-culture experiments with previously characterized Krabbe disease fibroblasts (Luzi et al., 1995, Rafi et al., 1995) to ascertain if they could be cross-corrected for GALC enzyme activity by the GALC NSCs. This evidence concerns the gene GALC and Krabbe disease.