It is extremely difficult to obtain an accurate diagnosis for PSP in Caucasian persons because of its low incidence.11 Based on its higher incidence in females, estrogen receptors were studied immunohistochemically.12, 13 Overexpression for ERbeta was found in 91.9% of PSP patients, compared with 45.8% in non‐small cell lung cancers.13 In the samples collected from 136 patients, women also accounted for the absolute majority (83.1%). Here, ESR1 is linked to lung cancer.