AKT1 and diabetic cardiomyopathy: Nicorandil is an antianginal agent that causes vasodilatation by dual action: one is releasing nitric oxide (NO) and the other is binding to ATP‐dependent K channel and opening it.11, 12 Recent studies show that nicorandil can reduce the level of reactive oxygen species(ROS) in endothelial cells and regulate the PI3K/Akt pathway.13, 14, 15 However, whether it can alleviate cardiomyocyte apoptosis in diabetic cardiomyopathy has not been reported yet.