APAF1 and neoplasm: Finally, Kaplan–Meier survival curves showed patients with low APAF1 expression had worse prognosis and shorter survival time, compared to those with high APAF1 expression (Fig. 6M), which was consistent with the results from tumor samples with detailed clinical information which was downloaded from TCGA database (APAF1 low n = 197, APAF1 high n = 198, P = 0.0101, Fig. S7A).