RARA and acute myeloid leukemia: Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) with characteristic biological and clinical features,1 comprising approximately 10% of de novo AML cases in younger adults.2 APL is present of a specific t(15;17) chromosomal translocation in the leukemic blast, which involves the promyelocyte (PML) gene on chromosome 15 to the retinoic acid receptor‐alpha (RARα) gene on chromosome 17.3 According to different breakpoints in PML and RARα, there are three isoforms of PML‐RARα fusion gene (FG): long (L, 55%), variant (V, 5%), and short (S, 45%).4