In 2017, a genome-wide association (GWA) study of Alzheimer’s disease (AD) showed that the rare nonsynonymous variant in the PLCG2 gene (rs72824905-G; p.Pro522Arg; NC_000016.9:g.81942028C > G) reduced AD risk (OR = 0.68, p = 5.4 × 10−10) [47]. This evidence concerns the gene PLCG2 and early-onset autosomal dominant Alzheimer disease.