PLCG2 and agammaglobulinemia: Indeed, known germline mutations in PLCG2 cause the immune disorders PLAID (PLCG2-associated antibody deficiency and immune dysregulation) and APLAID (autoinflammatory PLAID) [40, 46, 59] while somatic variants in PLCɣ2 are associated with resistance to treatment of leukemia [56] (reviewed in Koss et al. [32]).