Results of univariate analyses showed that AFP (>20/≤20, ng/mL), albumin (<3.5/≥3.5, g/dL), anatomical resection (presence/absence), Child‐Pugh classification (B/A), hepatitis C virus antibody (HCVAb) (Presence/Absence), ICGR15 (>13/≤13, %), LMR (<4.35/≥4.35), maximum tumor size (>3.5/≤3.5, cm), number of tumors (≥2/1), platelet count (<14/≥14, ×104/mm3), PIVKA‐II (>100/≤100, mAU/mL), portal hypertension (presence/absence), PT (<75/≥75, %) and TNM stage (III/I, II) were associated with RFS of HCC patients with low CLIP score (0‐1) (Table 5). This evidence concerns the gene AFP and portal hypertension.