In addition, mutations in such genes as TP53 and ATM detected in cfDNA at low allelic frequencies may be false positives as a result of clonal hematopoiesis.60 Corresponding tissue was not available for all samples to confirm TP53 status, and future studies will examine both prostate tumor tissue and blood leukocytes for genetic alterations. This evidence concerns the gene TP53 and prostate neoplasm.