In MDA-MB-231 breast cancer cells, knockdown of the Class IA PI3K p110α catalytic subunit or chemical inhibition of class I PI3K attenuates invadopodia formation and Akt activation, while activating mutations of PIK3CA (which encodes p110α) promote invadopodia formation and Akt activation (Yamaguchi et al., 2011). Here, AKT1 is linked to breast cancer.