AKT2 and breast neoplasm: This may contribute to the distinct ability of Akt1 to promote breast tumor initiation and impair invasion and migration (Hutchinson et al., 2004; Irie et al., 2005), while Akt2 enhances the invasive and metastatic capabilities of breast tumors (Arboleda et al., 2003; Irie et al., 2005).