In MDA-MB-231 breast cancer cells, knockdown of the Class IA PI3K p110α catalytic subunit or chemical inhibition of class I PI3K attenuates invadopodia formation and Akt activation, while activating mutations of PIK3CA (which encodes p110α) promote invadopodia formation and Akt activation (Yamaguchi et al., 2011). The gene discussed is AKT1; the disease is breast carcinoma.