Targeting the canonical WNT/β-catenin-TGF-β-PPARγ axis by upregulating PPARγ and downregulating the canonical WNT/TGF-β pathways might be of interest with respect to improving the development of the alveolar stage of BPD at birth and minimizing pulmonary fibrosis later during childhood and adulthood. The gene discussed is TGFB1; the disease is pulmonary fibrosis.