There is also evidence of a functional link between MTDH and pro-survival mechanisms mediated by the lymphoid enhancer binding factor 1 (LEF-1) and GSK3β components of the Wnt/β-catenin pathway in chronic lymphocytic leukemia (22) and hepatocellular carcinoma (23). The gene discussed is LEF1; the disease is B-cell chronic lymphocytic leukemia.