DEFB1 and oral cavity squamous cell carcinoma: Moreover, we find it perplexing that even though Joly et al. (13) reported no change in hBD-3 transcript expression between OSCC and normal cell lines, this is not reflected in the title of their study “Loss of human beta-defensin 1, 2, and 3 expression in oral squamous cell carcinoma.” Another perplexing result comes from an in situ hybridization study by Yoshimoto et al. (67).