To identify genes that are associated with CRC, we analyzed the expression of YTHDF1 in CRC on online databases The cancer genome atlas (TCGA) and Gene Expression Omnibus (GEO) profiling showed that YTHDF1 is significant upregulated in tumors compared with that in adjacent normal tissues in CRC (Figure 1A). Here, YTHDF1 is linked to colorectal carcinoma.