Most recently, a lipid‐conjugated drug‐incorporated oligonucleotide was developed for hitchhiking with endogenous serum albumin for cancer chemotherapy.88 By incorporating a hydrophobic lipid tail, floxuridine homomeric oligonucleotides inserted into the hydrophobic pocket of albumin to form complexes which accumulate at the tumor site by the enhanced permeability and retention (EPR) effect and internalize into the lysosomes of cancer cells after intravenous injection. The gene discussed is ALB; the disease is cancer.